Abstract
To investigate morbidity, mortality and microbiological response to fecal peritonitis induced in Wistar rats with permanent bilateral carotid ligation (PBCL). Fecal peritonitis was induced in 30 rats, with 10 animals in each group: Group1 - normal young animals; Group2 - normal mature animals; and Group3 - rats with PBCL after four months postoperative follow-up. Peritonitis was induced with 10% stool suspension. Morbidity and mortality were evaluated. The survival animals after seven days were euthanized for tests. For microbiological studies blood were collected from the carotids and right ventricle; and fragments of lung and peritoneum. The morbidity and mortality of young animals were significantly lower than in mature animals with and without PBCL. There was no difference in morbidity and mortality among mature rats with and without PBCL. The diversity of microorganisms producing septicemia was similar to native micro biota of the large bowel. The immune response was more efficient in young animals, represented by significant less morbidity and no natural mortality. PBLC did not affect morbidity and mortality in mature rats. The immune response to fecal peritonitis has age as an independent predictor.
Highlights
IntroductionThe elderly person is more susceptible to infection due to physiological changes of aging, decline in immune response and the presence of concomitant diseases
Sepsis remains a major cause of morbidity and mortality in elderly[1], if they undergo intra-abdominal surgery and stay in intensive therapy unit[2,3].The aging populations, the emergence of multiply resistant micro-organisms, the increasing use of invasive techniques, besides the increase in surgical procedures are among the factors that may explain the increased prevalence of septicemia, with peak usually occurring on the sixth decade[4].The elderly person is more susceptible to infection due to physiological changes of aging, decline in immune response and the presence of concomitant diseases
Chronic encephalic hypoxemia in rats can be achieved by permanent bilateral carotid ligation (PBCL), which generates chronic moderate hypoglycemia that is associated with ageing and dementia, besides neurocognitive impairment and systemic reactions such as sympathetic nervous system reactions, immune cellular suppression, and opportunity for spontaneous bacterial infections[6,7,8]
Summary
The elderly person is more susceptible to infection due to physiological changes of aging, decline in immune response and the presence of concomitant diseases. The declines in the function of T lymphocytes and cellular immunity and decrease the production of antibodies for immunization are extrinsic immunological changes that may enhance vulnerability to infection. The presence of diabetes mellitus, dementia, cerebrovascular disease, peripheral vascular disease and chronic obstructive pulmonary events are often found in the elderly that predisposes infections[5]. Chronic encephalic hypoxemia in rats can be achieved by permanent bilateral carotid ligation (PBCL), which generates chronic moderate hypoglycemia that is associated with ageing and dementia, besides neurocognitive impairment and systemic reactions such as sympathetic nervous system reactions, immune cellular suppression, and opportunity for spontaneous bacterial infections[6,7,8]
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