Abstract
Overuse of antibiotics such as enrofloxacin (ENR) can lead to their residues in environment and food and ultimately endanger human health. It's essential to build a rapid, sensitive and selective biosensor to detect the antibiotics residues. Herein, an autofluorescence free near-infrared (NIR) laser excited functionalized upconversion nanoparticles (UCNPs) based turn-on aptasensor for ENR detection is presented. Efficient Fӧrster resonance energy transfer (FRET) from aptamer modified core-shell UCNPs with highly enhanced upconversion (UC) luminescence to MnO2 nanosheets occurs. Based on the UC luminescence recovery of the UCNPs-MnO2 aptasensor caused by ENR, this luminescence turn-on UCNPs-MnO2 aptasensor shows highly sensitive and selective detection of ENR in linear range of 0.5–3000 ng mL−1 with a limit of detection (LOD) at 0.0642 ng mL−1 in diluted commercially available milk solution without pretreatment. The proposed aptasensor demonstrates high sensitivity, excellent selectivity, no background autofluorescence for high signal-to-noise ratio and low LOD for the fast detection of antibiotics residue, holding great potential for environmental and food safety detection of antibiotics.
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