Autoantibody detection is not recommended for chronic pancreatitis: a cross-sectional Study of 557 patients

Xiang-Peng Zeng,Hui Chen,Hong-Lei Guo,Jun-Tao Ji,Hao Liang ,Tingting Du ,Teng Wang,Lisheng Wang ,Di Zhang,Ming‐Hao Liu ,Bai-Rong Li,Ting Xie,Yang Bi ,Zefeng Xu ,Lei Xin,Jun Pan,Jin‐Huan Lin ,Zhuan Liao,Zhao‐Shen Li ,Anmei Deng ,Tingting Liu ,Wenbin Zou ,Lin He,Dan Wang,Zhi-Jie Cong,Liang–Hao Hu

doi:10.1186/s12876-019-0947-7

Abstract

BackgroundAutoimmune factor was regarded as one of the risk factors in the pathogenesis of chronic pancreatitis (CP), especially for autoimmune pancreatitis (AIP). However, whether autoimmune factor plays a role in non-AIP CP or not was unknown.MethodsHospitalized patients with non-AIP CP from January 2010 to October 2016 were detected for 22 autoantibodies at the time of hospital admission. Autoantibodies with frequency > 0.5% were enrolled to calculate the frequency in historial healthy controls through literature search in PubMed. Differentially expressed autoantibodies were determined between patients and historial healthy controls, and related factors were identified by multivariate logistic regression analysis.ResultsIn a total of 557 patients, 113 cases were detected with 19 kinds of positive autoantibodies, among them anti-β2-glycoprotein I (β2-GPI) antibody was most frequent (9.16%). Compared with historial healthy controls, the frequencies of serum β2-GPI and anti SS-B antibody in patients were significantly higher, while frequencies of anti-smooth muscle antibody and anticardiolipin antibody were significantly lower (all P < 0.05). Multivariate logistic regression analysis result showed that diabetes mellitus (OR = 2.515) and common bile duct stricture (OR = 2.844) were the risk factors of positive β2-GPI antibody in patients while diabetes mellitus in first−/second−/third-degree relatives (OR = 0.266) was the protective factor. There were no related factors for other three differentially expressed autoantibodies.ConclusionsFour autoantibodies were expressed differentially between patients with non-AIP CP and historial healthy controls. Due to limited significance for diagnosis and treatment of chronic pancreatitis, autoantibodies detection is not recommended conventionally unless suspected of AIP.

Highlights

Autoimmune factor was regarded as one of the risk factors in the pathogenesis of chronic pancreatitis (CP), especially for autoimmune pancreatitis (AIP)
Search strategy In order to compare the frequency of autoantibodies between non-AIP CP patients and healthy controls, a literature search for autoantibodies with frequency > 0.5% was performed through PubMed to identify eligible studies published
General characteristics of Study subjects After exclusion of 98 patients, which consists of 91 patients diagnosed with AIP, 3 patients diagnosed with uarthritis, 1 patient diagnosed with leukoderma, and 1 patient newly diagnosed with rheumatoid arthritis (RA), a total of 575 non-AIP CP patients were enrolled in the study, including 393 males and 164 females

Summary

Introduction

Autoimmune factor was regarded as one of the risk factors in the pathogenesis of chronic pancreatitis (CP), especially for autoimmune pancreatitis (AIP). Whether autoimmune factor plays a role in non-AIP CP or not was unknown. Autoimmune factor was regarded as one of the risk factors in the pathogenesis of CP. Autoimmune is regarded as the major definite pathogenesis of AIP, but whether autoimmune factor plays a role in non-AIP CP or not was unknown. In the past few years, novel specific antibodies have emerged to help the diagnosis and differential diagnosis of AIP [12,13,14]. There have been no researches for specific antibodies of non-AIP CP. We prospectively detected 22 common autoantibodies in 557 non-AIP CP patients to initially investigate the clinical significance of autoantibody detection

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Results

Discussion

Conclusion