Autoantibodies to thyroid antigens levels in the population of the Russian Arctic at different levels of blood dopamine.

Abstract

Neuroimmunoendocrine regulation of the thyroid gland involves the use of autoantibodies as regulatory molecules to stimulate or reduce the activity of the tissues of the organ itself. A huge number of regulatory signal molecules and factors, acting directly or indirectly, often plays a much more significant role, both in ensuring normal activity and in pathological processes. In this regard, it was interesting for us to determine the possible effect of dopamine at its various concentrations in the blood on the levels of thyroglobulin and antibodies to thyroid antigens. A survey of 110 men and 206 women aged 22 to 75 years who were born and lived in the Arctic zone of the Russian Federation and had no diseases of the endocrine and immune system was conducted. Dopamine concentrations were determined in blood plasma, thyroid stimulating hormone (TSH), thyroglobulin (TG), antibodies to thyroperoxidase (at-TPO) and thyroglobulin (at-TG) in serum. Higher concentrations of thyrotropin and thyroglobulin and lower concentrations of at-TG and at-TPO were shown with increasing dopamine levels from undetectable values to normative and excess levels. We explain this by the influence of dopamine on a-adrenoreceptors of antibody-producing cells and changes in the secretion of immunoglobulins class G, subclasses of which include at-TG and at-TPO. The appearance of different from zero values of autoantibodies concentrations in themselves, we associate with the negative impact of the conditions of the North and the prenosological state of the organism. Their higher values in women with low levels of dopamine can be explained by the lack of its immunomodulatory activity.