Abstract
Background The main processes in the pathogenesis of cerebral malaria caused by Plasmodium falciparum involved sequestration of parasitized red blood cells and immunopathological responses. Among immune factors, IgG autoantibodies to brain antigens are increased in P. falciparum infected patients and correlate with disease severity in African children. Nevertheless, their role in the pathophysiology of cerebral malaria (CM) is not fully defined. We extended our analysis to an Indian population with genetic backgrounds and endemic and environmental status different from Africa to determine if these autoantibodies could be either a biomarker or a risk factor of developing CM.
Highlights
The main processes in the pathogenesis of cerebral malaria caused by Plasmodium falciparum involved sequestration of parasitized red blood cells and immunopathological responses
IgG autoantibodies to brain antigens are increased in P. falciparum infected patients and correlate with disease severity in African children
We extended our analysis to an Indian population with genetic backgrounds and endemic and environmental status different from Africa to determine if these autoantibodies could be either a biomarker or a risk factor of developing cerebral malaria (CM)
Summary
The main processes in the pathogenesis of cerebral malaria caused by Plasmodium falciparum involved sequestration of parasitized red blood cells and immunopathological responses. Auto-antibodies targeting brain antigens in Plasmodium falciparum infected patients as biomarkers of Cerebral Malaria Devendra Bansal1,2, Fabien Herbert1, Prakash Deshpande2, Christophe Bécavin3, Vincent Guiyedi1, Ilaria de Maria4, Pierre-André Cazenave1, Gyan Chandra Mishra2, Cristiano Ferlini4, Constantin Fesel5, Arndt Benecke3, Sylviane Pied1*
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