Abstract
Spondyloarthritis (SpA) is an inflammatory rheumatic disease with diverse clinical presentation. The diagnosis of SpA remains a big challenge in daily clinical practice because of the limitation in specific biomarkers of SpA, more biomarkers are still needed for SpA diagnosis and disease activity monitoring. In the past, SpA was considered predominantly as auto-inflammatory disease vs. autoimmune disease. However, in recent years several researches demonstrated a broad autoantibody response in SpA patients. Study also indicated that mice lack of ZAP70 in T cell develop SpA featured inflammation. These studies indicated the autoimmune features of SpA and gave rise to the potential use of autoantibody in SpA management. In this article, we reviewed recent reports of autoantibodies associated with SpA patients, revealing the autoimmune features of SpA, suggesting the hypothesis that SpA was also an autoimmune disease, studies about the autoimmune features might provide more insights in the pathogenesis of SpA. In addition, as there are two opposite conclusions in the role of anti-CD74 autoantibody in the diagnosis of SpA, we also gave our own data on the diagnostic value of anti-CD74 in Chinese SpA patients. Though our data indicated that anti-CD74 might not be a good biomarker for SpA diagnosis in Asian people, CD74 was still a good molecule target in the research of SpA pathogenesis.
Highlights
Spondyloarthritis (SpA) is an inflammatory rheumatic disease with diverse clinical presentation, including psoriatic arthritis, reactive arthritis, arthritis related to inflammatory bowel disease, a subgroup of juvenile idiopathic arthritis, and ankylosing spondylitis (AS) [1]
We reviewed recent reports of autoantibodies associated with SpA patients to further reveal the autoimmune features of SpA and potential autoantigens
Based on these research results, Michele Maria Luchetti et al further studied the significance of anti-SOST-IgG in the diagnosis of SpA, they focused their attention on spondyloarthritisassociated inflammatory bowel diseases (SpA/IBD), one of the group of SpA
Summary
Spondyloarthritis (SpA) is an inflammatory rheumatic disease with diverse clinical presentation, including psoriatic arthritis, reactive arthritis, arthritis related to inflammatory bowel disease, a subgroup of juvenile idiopathic arthritis, and ankylosing spondylitis (AS) [1]. Higher level of anti-HSP65 in patients with AS than in healthy controls was shown in a research, but the number of patients included in this study was relatively small, they only compared 43 AS patients with 11 patients with low back pain but no AS [21].
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