Abstract
Alzheimer’s disease (AD) is a prevalent and debilitating neurodegenerative disorder in the elderly. The etiology of AD has not been fully defined and currently there is no cure for this devastating disease. Compelling evidence suggests that the immune system plays a critical role in the pathophysiology of AD. Autoantibodies against a variety of molecules have been associated with AD. The roles of these autoantibodies in AD, however, are not well understood. This review attempts to summarize recent findings on these autoantibodies and explore their potential as diagnostic/ prognostic biomarkers for AD, their roles in the pathogenesis of AD, and their implications in the development of effective immunotherapies for AD.
Highlights
Alzheimer's disease (AD) is the most prevalent age-related neurodegenerative disorder
The neuropathological hallmarks of AD brains include the accumulation of amyloid-β protein (Aβ) in neuritic plaques and cerebral vessels and neurofibrillary tangles consisting of hyper-phosphorylated tau proteins[3]
Recent clinical and experimental studies suggest that these autoa ntibodies may have the potential to serve as diagnostic/prognostic biomarkers for AD; some may contribute to the pathogenesis of AD, and others may play a protective role, facilitating the development of effective immunotherapies for AD
Summary
Alzheimer's disease (AD) is the most prevalent age-related neurodegenerative disorder. A later study reported the detection of autoantibodies against tau in both unphosphorylated and phosphorylated forms in the serum of a small number of AD and healthy subjects and provided some preliminary evidence for a higher level of anti-phosphorylated-tau autoantibodies of IgM class in AD patients than in controls[31].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
