Abstract
BackgroundBrain autoimmunity has been reported in patients with preceding infection of the central nervous system by herpesviridae. It has been hypothesized that neuronal damage releasing antigens might trigger secondary immune response. The objective of the study was to investigate whether brain damage due to spontaneous subarachnoid haemorrhage (SAH) or intracerebral haemorrhage (ICH) induces reactivity against neuronal surface proteins.MethodsPatients with spontaneous SAH and ICH, who had cerebrospinal fluid (CSF) and serum sampling within 2 weeks after disease onset (baseline) and afterwards at least 10 days later (follow-up), were included. Antibodies against NMDA, GABA-B, AMPA-1/− 2 receptor, LGI1 and CASPR2 were determined by indirect immunofluorescence.ResultsA total of 43 SAH and 11 ICH patients aged 62 (±12) years (65% females) had simultaneous CSF/ serum sampling median 5 and 26.5 days after disease onset. At baseline, all CSF samples were collected via ventricular drainage, at follow-up 20 (37.0%) patients had CSF collection by lumbar puncture because ventricular drain had been already removed. All CSF and serum samples at baseline and follow-up tested negative for antibodies against NMDA, GABA-B, AMPA-1/− 2 receptor, LGI1 and CASPR2.ConclusionsImmunoreactivity against common neuronal surface proteins was not observed within the early disease course of spontaneous SAH and ICH.
Highlights
Brain autoimmunity has been reported in patients with preceding infection of the central nervous system by herpesviridae
Spontaneous subarachnoid haemorrhage (SAH) and spontaneous intracerebral haemorrhage (ICH) are both severe neurological disorders that result in brain injury due to several mechanisms including primary mechanical tissue damage caused by the bleeding and secondary effects such as inflammatory processes, oxidative stress responses, brain edema and in case of SAH delayed cerebral ischemia [1, 2]
We aimed to investigate whether acute brain damage due to spontaneous SAH or ICH induces the formation of antibodies against neuronal surface proteins in the early and post-acute phase
Summary
Brain autoimmunity has been reported in patients with preceding infection of the central nervous system by herpesviridae. It has been hypothesized that neuronal damage releasing antigens might trigger secondary immune response. The objective of the study was to investigate whether brain damage due to spontaneous subarachnoid haemorrhage (SAH) or intracerebral haemorrhage (ICH) induces reactivity against neuronal surface proteins. Spontaneous subarachnoid haemorrhage (SAH) and spontaneous intracerebral haemorrhage (ICH) are both severe neurological disorders that result in brain injury due to several mechanisms including primary mechanical tissue damage caused by the bleeding and secondary effects such as inflammatory processes, oxidative stress responses, brain edema and in case of SAH delayed cerebral ischemia [1, 2]. We aimed to investigate whether acute brain damage due to spontaneous SAH or ICH induces the formation of antibodies against neuronal surface proteins in the early and post-acute phase.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
