Abstract
Background Biologic agents may cause auto-antibody formation and drug induced lupus but no paediatric guidelines exist regarding monitoring of auto-antibodies. The UK Royal College of Nursing Guidance advises checking ANA and anti-dsDNA before starting biologic treatment and repeating anti-dsDNA if concerned. The Alder Hey protocol tested an autoantibody profile (Table 1, 2) 3-6 monthly for data entry for the British Paediatric and Adolescent Rheumatology (BSPAR) Biologics and New Drugs Registry (BDNR) and children with day ward IV biologic administration often had automatic antibodies testing 4-6 weekly.
Highlights
Biologic agents may cause auto-antibody formation and drug induced lupus but no paediatric guidelines exist regarding monitoring of auto-antibodies
Auto-antibody testing for children on biologic therapies for rheumatological conditions: results of audit
All patients on biologics were included with data on auto-antibodies collated using the hospital computer system
Summary
Biologic agents may cause auto-antibody formation and drug induced lupus but no paediatric guidelines exist regarding monitoring of auto-antibodies. Auto-antibody testing for children on biologic therapies for rheumatological conditions: results of audit Julie Duncan*, Jill Heath, Eileen Baildam, Gavin Cleary, Michael Beresford, Liza J McCann From 18th Pediatric Rheumatology European Society (PReS) Congress Bruges, Belgium. Background Biologic agents may cause auto-antibody formation and drug induced lupus but no paediatric guidelines exist regarding monitoring of auto-antibodies.
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