Abstract
An autoantibody of Anti-M specificity developed following haemodialysis and renal transplantation in a 25-yr-old man with rapidly progressive glomerulonephritis. Only 4 cases of Anti-M occurring as an autoantibody have been previously reported. The antibody was readily absorbed by and eluted from the patient's own red cells and was shown to be IgM globulin reacting optimally at 4°C. The patient's red cells appeared to have a normal M antigen. The antibody displayed similar characteristics to the more commonly found Anti-M alloantibody. There was no evidence of immune haemolysis. The antibody did not demonstrate features similar to the Anti-N like antibodies which have been described in patients undergoing chronic haemodialysis programmes. The significance of the renal transplant in relation to the formation of the antibody remains obscure.
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