Authors' response.

Abstract

We appreciate the interest from the readers of AJO-DO in our article (Varella A, Revankar AV, Patil AK. Low-level laser therapy increases interleukin 1β in gingival crevicular fluid and enhances the rate of tooth movement in humans. Am J Orthod Dentofacial Orthop 2018;154:535-44). We would like to clarify some misunderstandings related to the article. IL-10 levels were not assessed because it was not an objective in this study. The study aimed at assessing the levels of proinflammatory cytokine 1β in conjunction with LLLT. IL-10, being an anti-inflammatory cytokine, would have no role in bone resorption associated with tooth movement. Previous studies have shown that the levels of IL-10 fall in orthodontic tooth movement.1Karaduman B. Uraz A. Altan G.N. et al.Changes of tumor necrosis factor-α, interleukin-10, and tartrate-resistant acid phosphatase5b in the crevicular fluid in relation to orthodontic movement.Eur J Inflamm. 2015; 13: 3-13Google Scholar As readers have rightly pointed out, IL-10 assessment and its ratio with IL-1β would be more relevant in periodontal disease assessment than in tooth movement. The effectiveness of LLLT in reducing pain associated with tooth movement was not an objective in this study and therefore was not investigated. Low-level laser therapy increases interleukin-1β in gingival crevicular fluid and enhances the rate of orthodontic tooth movementAmerican Journal of Orthodontics and Dentofacial OrthopedicsVol. 155Issue 4PreviewWe read with great interest the well performed study in the October issue, “Low-level laser therapy increases interleukin-1β in gingival crevicular fluid and enhances the rate of orthodontic tooth movement” (Varella AM, Revankar AV, Patil AK. Am J Orthod Dentofacial Orthop 2018;154:535-44.e5), on the effects of low-level laser therapy on interleukin (IL) 1β levels in gingival crevicular fluid and its correlation with orthodontic tooth movement. Full-Text PDF