Author's response to: “Letter to the Editor: The atherogenic index of plasma as a predictor of mortality in patients with COVID-19”

Abstract

First, we would like to thank you for your interest in our article entitled, “The atherogenic index of plasma as a predictor of mortality in patients with COVID-19”.1Turgay Yıldırım Ö Kaya Ş The atherogenic index of plasma as a predictor of mortality in patients with COVID-19.Heart Lung. 2021 Mar-Apr; 50: 329-333https://doi.org/10.1016/j.hrtlng.2021.01.016Abstract Full Text Full Text PDF PubMed Scopus (18) Google Scholar,2Qazi M Kumar S Khatri M Letter to the Editor: the atherogenic index of plasma as a predictor of mortality in patients with COVID-19.Heart Lung. 2023 Jan-Feb; 57 (Epub 2022 Sep 14. PMID:36167745PMCID: PMC9472793): 301https://doi.org/10.1016/j.hrtlng.2022.09.006Abstract Full Text Full Text PDF PubMed Scopus (0) Google Scholar As you mentioned, our study hypothesized that besides stating that the atherogenic index shows mortality during the COVID-19 process, SARS-CoV-2 may also have an effect on lipid metabolism. This study was a study published in the early stages of the pandemic and was one of the first studies to express an opinion on this subject.1Turgay Yıldırım Ö Kaya Ş The atherogenic index of plasma as a predictor of mortality in patients with COVID-19.Heart Lung. 2021 Mar-Apr; 50: 329-333https://doi.org/10.1016/j.hrtlng.2021.01.016Abstract Full Text Full Text PDF PubMed Scopus (18) Google Scholar Thank you again for your interest in the article. You stated that we should mention that atherogenic index of plasma has a predictive potential for ischemc heart diseases. We actually mentioned the relationship between AIP and several illnesses like cardiovascular diseases, atherosclerosis, diabetes mellitus, hypertension.3Onat A Can G Kaya H Hergen¸c G. Atherogenic index of plasma" (log10 triglyceride/high-density lipoprotein-cholesterol) predicts high blood pressure, diabetes, and vascular events.J Clin Lipidol. 2010; 4: 89-98https://doi.org/10.1016/j. jacl.2010.02.005Crossref PubMed Scopus (0) Google Scholar, 4Yildiz G Duman A Aydin H et al.Evaluation of association between atherogenic index of plasma and intima-media thickness of the carotid artery for subclinic atherosclerosis in patients on maintenance hemodialysis.Hemodial Int. 2013; 17: 397-405https://doi.org/10.1111/hdi.12041Crossref PubMed Scopus (32) Google Scholar, 5Dobiasova M Frohlich J Sedova M Cheung MC Brown BG Cholesterol esterification and atherogenic index of plasma correlate with lipoprotein size and findings on coronary angiography.J Lipid Res. 2011; 52: 566-571https://doi.org/10.1194/jlr.P011668Abstract Full Text Full Text PDF PubMed Scopus (132) Google Scholar, 6Niroumand S Khajedaluee M Khadem-Rezaiyan M et al.Atherogenic Index of Plasma (AIP): a marker of cardiovascular disease.Med J Islam Repub Iran. 2015; 29 (Published 2015 Jul 25): 240PubMed Google Scholar, 7Turgay Yıldırım O Aksit E Aydın F Huseyinoglu Aydın A. Evaluation of atherogenic index of plasma levels at hypertensive patients.ACEM. 2019; 4: 72-75https://doi.org/10.25000/acem.563986Crossref Google Scholar Studies have shown that ethnic changes are important in the COVID-19 pandemic.8Nafilyan V Islam N Mathur R Ayoubkhani D Banerjee A Glickman M Humberstone B Diamond I Khunti K. Ethnic differences in COVID-19 mortality during the first two waves of the Coronavirus Pandemic: a nationwide cohort study of 29 million adults in England.Eur J Epidemiol. 2021 Jun; 36: 605-617https://doi.org/10.1007/s10654-021-00765-1Crossref PubMed Scopus (30) Google Scholar As you pointed out, mentioning ethnic differences would have enriched our work. Since our study was a single-center study, we did not feel the need to add this information to our study, since the region we are in is not an ethnically diverse region. However, the studies carried out during the pandemic period revealed the importance of this issue. You mentioned that the units in AIP calculation should be mmol. If you look at the literature, you can see that the mg/dl unit is used in many studies in the calculation of AIP, similar to our study.9Uzunget SB Sahin KE. Atherogenic index of plasma is an independent predictor of mitral annular calcification.BMC Cardiovasc Disord. 2022 Nov 30; 22 (PMID:36451082PMCID: PMC9710030): 511https://doi.org/10.1186/s12872-022-02891-4Crossref PubMed Scopus (0) Google Scholar,10Toprak K. Atherogenic index of plasma is an independent risk factor for contrast induced nephropathy in patients with non-ST elevation myocardial infarction.Angiology. 2022 Jun 24; (Epub ahead of printPMID:35750499)33197221110723https://doi.org/10.1177/00033197221110723Crossref Scopus (0) Google Scholar In addition, AIP is calculated as log (Triglyceride/HDL-C). As long as the units of both triglyceride and HDL-C are the same, the ratio will always be the same, so the unit we use during the study will not make a difference on the study. Letter to the Editor: The atherogenic index of plasma as a predictor of mortality in patients with COVID-19Heart & Lung: The Journal of Cardiopulmonary and Acute CareVol. 57PreviewTo the Editor Full-Text PDF