Abstract
Author's response: False-positive results with rapid diagnostic test for dengue in Thailand.
Highlights
The dengue virus (DENV) IgG determination carried out at HUSLAB, Helsinki University Hospital, which is responsible for most of the dengue diagnostics in Finland, is based on an in-house immunofluorescence assay (IFA) that, together with a commercial IgM EIA testing, would have shown DENV antibody response at the time of sampling in Finland [4]
The IgG test is strongly cross-reactive between flaviviruses
Similar IgG titres are typically obtained for both the DENV and Zika virus (ZIKV) antigens, regardless of the infecting virus [6]
Summary
The dengue virus (DENV) IgG determination carried out at HUSLAB, Helsinki University Hospital, which is responsible for most of the dengue diagnostics in Finland, is based on an in-house immunofluorescence assay (IFA) that, together with a commercial IgM EIA testing, would have shown DENV antibody response at the time of sampling in Finland [4]. The IgG test is strongly cross-reactive between flaviviruses.
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