Abstract
We appreciate the comment on our article.1 Dr. Stoiloudis reports the case of an otherwise healthy young male individual who developed a wake-up acute ischemic stroke after the second dose of BNT162b2. It is of interest that their patient developed a fever in close temporal association to vaccination, which may be explained by vaccination reactogenicity. Additional research on the potential pathophysiologic pathways for immunization-related strokes is needed. It would be interesting to clarify the stroke etiologic approach in this patient because the development of an acute stroke in close temporal association to the vaccine does not exclude other common stroke causes among young adults.2
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