Abstract
We read with interest the comments by Professor Kawada on our article.1 As described in the article, all participants were evaluated 3 times within strict 1-year intervals; there were no missed visits or missing data. Furthermore, we defined disease onset as the start of clinical symptoms of limb-girdle muscular dystrophy autosomal recessive type 12 (LGMDR12) and thereby excluded patients with isolated hyperCKemia for increased phenotypic homogeneity.
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