Author response: Pathologic Thr175 tau phosphorylation in CTE and CTE with ALS.

Abstract

While I appreciate the interest of Glass et al. in our article,1 it is unfortunate that they have misinterpreted it. Most importantly, Glass suggests that “the finding of tau inclusions in the spinal cord of amyotrophic lateral sclerosis (ALS) cases is not unusual in our experience.” This would be at odds with the dogma that—with the exception of the Western Pacific variant of ALS and chronic traumatic encephalopathy (CTE)–ALS—there is never evidence of pathologic tau deposition in the spinal cord of patients with sporadic ALS. I would strongly urge the authors to assemble their case experience and submit it for peer review as it would be an important contribution to the literature.