Abstract
We thank Dr. Vavougios and Vaira et al. for their letters on our study,1 which reported 2 patients infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) who acutely presented with Miller Fisher syndrome and polyneuritis cranialis, respectively. We agree with Dr. Vavougios that indolent self-limiting neuroinvasion could manifest as self-limiting anosmia, whereas the ganglioside-virus interaction would offer a prominent target for an antiganglioside antibody response as in our patient with Miller Fisher syndrome. In addition, we also agree with Dr. Vaira et al. regarding anosmia in coronavirus disease 2019 (COVID-19). Indeed, SARS-CoV-2 could negatively influence the activity of olfactory neurons through inflammatory mechanisms. Further study is needed regarding whether ageusia could instead be caused by the direct action of the SARS-CoV-2 on the ACE-2 receptors of the taste buds.
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