Abstract
We read with interest, but also amusement, the comments by Meyer et al1Meyer C.H. Rodrigues E.B. Kroll P. Lines of Blaschko.Ophthalmology. 2008; 115: 1855Abstract Full Text Full Text PDF PubMed Scopus (5) Google Scholar and MacDonald et al2MacDonald I.M. Sui R. Zein W. Lines of Blaschko and choroideremia.Ophthalmology. 2009; 116: 1017-1018Abstract Full Text Full Text PDF PubMed Scopus (2) Google Scholar in their Letters to the Editor. The interest was in their discussions of the Lines of Blaschko. The amusement was related to their attributing us with drawing an analogy between mosaic dysfunction of the retina in carriers of choroideremia with fundus changes observed in patients with congenital hypertrophy of the retinal pigment epithelium (CHRPE).3Vajaranant T.S. Fishman G.A. Szlyk J.P. et al.Detection of mosaic retinal dysfunction in choroideremia carriers: electroretinographic and psychophysical testing.Ophthalmology. 2008; 115: 723-729Abstract Full Text Full Text PDF PubMed Scopus (29) Google Scholar We have re-read our original publication,3Vajaranant T.S. Fishman G.A. Szlyk J.P. et al.Detection of mosaic retinal dysfunction in choroideremia carriers: electroretinographic and psychophysical testing.Ophthalmology. 2008; 115: 723-729Abstract Full Text Full Text PDF PubMed Scopus (29) Google Scholar and nowhere did we find any reference to CHRPE. Nonetheless, we concur with the sentiments expressed by our colleagues that the mosaic pattern of fundus and fundus pigmentary changes in carriers of choroideremia do not suggest any comparison with the distribution of pigmentary changes observed in CHRPE. Lines of Blaschko and ChoroideremiaOphthalmologyVol. 116Issue 5PreviewVajaranant et al1 describe a mosaic pattern of localized retinal dysfunction, when testing choroideremia carriers, which is conventionally related to the process of Lyonization. This finding reminded them of the pattern seen in congenital hypertrophy of the retinal pigment epithelium (CHRPE). In a subsequent letter, Drs. Meyer, Rodrigues and Kroll,2 point to the lines of Blaschko as embryologically important and distinct from the dermatomes, which reflect cutaneous innervation by sensory nerves. Full-Text PDF
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