Author index for volume 87, number 1

Abstract

Chick embryo fibroblast monolayers infected with influenza virus (WSN strain) were treated with either actinomycin D or cycloheximide at various times after infection. Analysis of cell homogenates indicated that in the presence of actinomycin D, synthesis of RNA complementary to virion type RNA was preferentially inhibited. Consequently, no labeled polysomes are found in cells so treated, although virion-type RNA, isolated as the RNP, was found. Cycloheximide, on the other hand, while suppressing the synthesis of complementary type RNA, completely inhibited the synthesis of virion-type RNA.These results confirm and extend the work of Scholtissek and Rott (1970) that showed the same differential effect of these two drugs on RNA synthesis and are added evidence that in influenza virus-infected cells the messenger RNA is that RNA which is complementary to the RNA found in virions.