Abstract
The basic repeating unit of chromatin is the nucleosome, which is made of two copies each of the core histones H2A, H2B, H3 and H4. Histones are frequently post-translationally modified. These histone modifications correlate with functional elements, such as promoters and enhancers, and the activity status of the DNA in a cell-type-specific manner. Here we describe how to determine the localization of histone modifications by the analysis of ChIP-seq data.
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