Abstract
BackgroundThe association between Aurora-A V57I (rs1047972, G>A) polymorphism and cancer susceptibility has been widely studied. However, the results are inconsistent.Methodology/Principal FindingsTo obtain a more precise evaluation of the relationship, we performed a meta-analysis of 14 case-control studies involving a total of 11,245 cancer cases and 16,024 controls. Our results demonstrated that there was a borderline evidence of an association between the Aurora-A V57I polymorphism and the decreased risk of overall cancer in two genetic models: AA vs. GA+GG and AA vs. GG. In a stratified analysis by cancer type, significant association between Aurora-A V57I polymorphism and the decreased risk of breast cancer was identified in one genetic model: AA vs. GG. In a stratified analysis by ethnicity, in three genetic models, significant decreased cancer risk was observed among Caucasians (AA vs. GA+GG; AA vs. GG and A vs. G) instead of Asians. Furthermore, a stratified analysis by ethnicity in breast cancer subgroup, five genetic models (AA+GA vs. GG; AA vs. GA+GG; AA vs. GG; AA vs. GA and A vs. G), significant decreased cancer risk was observed among Caucasians, but not among Asians. A slight publication bias was observed in our meta-analysis, thus nonparametric “trim-and-fill” method was utilized to detect the stability of our results. The adjusted odds ratios and confidence intervals showed that Aurora-A V57I polymorphism might be a protective factor for cancer risk, suggesting the reliability of our findings.ConclusionIn summary, this meta-analysis suggests that Aurora-A V57I polymorphism may be a protective factor for cancer risk.
Highlights
Aurora-A protein, known as STK15/BTAK, belong to the Aurora family of cell cycle-regulating serine/threonine kinase.Aurora-A plays a pivotal role of mitotic centrosome separation, maturation and spindle formation and stability [1,2]
In summary, this meta-analysis suggests that Aurora-A V57I polymorphism may be a protective factor for cancer risk
The evaluation of the association between single nucleotide polymorphisms (SNPs) in cell cycle regulation genes and cancer risk would be beneficial for further studies
Summary
Aurora-A protein, known as STK15/BTAK, belong to the Aurora family of cell cycle-regulating serine/threonine kinase. Aurora-A plays a pivotal role of mitotic centrosome separation, maturation and spindle formation and stability [1,2]. Aurora-A is overexpressed in the passage from G2 to. M, degraded after termination of cytokinesis, and expressed at significant low levels in G1 and S passage, partly because of effective post-translational degradation through the ubiquitination machinery [3]. Overexpression and altering activity of Aurora-A leads to genomic instability, destroys the accuracy of centrosome duplication, and results in cellular transformation and malignance [4]. The evaluation of the association between single nucleotide polymorphisms (SNPs) in cell cycle regulation genes and cancer risk would be beneficial for further studies. The association between Aurora-A V57I (rs1047972, G.A) polymorphism and cancer susceptibility has been widely studied.
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