Abstract
Accurate chromosome segregation requires the perfect spatiotemporal rearrangement of the cellular cytoskeleton. Isolated more than two decades ago from Drosophila, Aurora A is a widespread protein kinase that plays key roles during cell division. Numerous studies have described the localisation of Aurora A at centrosomes, the mitotic spindle, and, more recently, at mitotic centromeres. In this review, we will summarise the cytoskeletal rearrangements regulated by Aurora A during cell division. We will also discuss the recent discoveries showing that Aurora A also controls not only the dynamics of the cortical proteins but also regulates the centromeric proteins, revealing new roles for this kinase during cell division.
Highlights
Numerous mitotic events are controlled by phosphorylation signalling pathways
Centrosome maturation is marked by the accumulation of the gamma-tubulin ring complex on the centrosome, which promotes extensive microtubule (MT) nucleation [29]
CDK5RAP2 displays a binding site for γ-tubulin ring complex, Kinase 5 Regulatory subunit-Associated Protein 2 (CDK5RAP2) (Cnn in Drosophila) that undergoes strong microtubule (MT) nucleation is induced at the centrosome surface
Summary
Numerous mitotic events are controlled by phosphorylation signalling pathways. In general, extensive phosphorylation events orchestrate the entry into mitosis, whereas waves of dephosphorylation mark the exit [1]. C has remained unclear a long time recent kinases studies A and B have shown it is essential for the control of meiotic spindle assembly in mammalian oocytes based on their different cellular localisation [6,19] Both enzymes share major[16,17]. Centrosome maturation is marked by the accumulation of the gamma-tubulin ring complex (γTuRC) on the centrosome, which promotes extensive microtubule (MT) nucleation [29] This event is essential, in most cases, to ensure bipolarisation and the correct spatiotemporal assembly of the spindle in mitotic cells. CDK5RAP2 displays a binding site for γ-tubulin ring complex (γTuRC), Kinase 5 Regulatory subunit-Associated Protein 2 (CDK5RAP2) (Cnn in Drosophila) that undergoes strong microtubule (MT) nucleation is induced at the centrosome surface. The right part of the picture shows the location of each Aurora A activated pool (light green)
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