Abstract
IntroductionCentral nervous system (CNS) tumors comprise 15–20% of all malignancies occurring in childhood and adolescence. Previous researches have shown that overexpression and amplification of the AURKA gene could induce multiple human malignancies, with which the connection of CNS tumor susceptibility has not been extensively studied.Material and methodsIn this study, we assessed whether and to what extent AURKA gene single nucleotide polymorphisms (SNPs) (rs1047972 C > T, rs2273535 T > A, rs8173 G > C) were associated with CNS tumor susceptibility, based on a case–control analysis in 191 CNS tumor patients and 248 controls. We determined this correlation using odds ratios (ORs) and 95% confidence intervals (CIs).ResultsAURKA gene rs8173 G > C exhibited a crucial function to CNS tumor susceptibility fall-off (GC/CC vs. GG: adjusted OR = 0.68, 95% CI = 0.46–0.998, P = 0.049). In addition, the combined effect of lowering the risk of developing CNS tumors was more pronounced in carriers with 3 protective genotypes than others (adjusted OR = 0.55, 95% CI = 0.31–0.98, P = 0.044). Further stratification analysis illustrated that the existence of rs8173 GC/CC and three protective genotypes lowered CNS tumor risk in some subgroups.ConclusionsOur research suggested that the AURKA gene rs8173 G > C could significantly reduce CNS tumor susceptibility in Chinese children. More functional experiments are needed to explore the role of the AURKA gene rs8173 G > C.
Highlights
Central nervous system (CNS) tumors comprise 15–20% of all malignancies occurring in childhood and adolescence
Rs8173 G > C exhibited a prominently correlation with decreased CNS tumor risk under the dominant model (GC/CC vs. GG: adjusted odds ratios (ORs) = 0.68, 95% confidence intervals (CIs) = 0.46–0.998, P = 0.049), which means the effect of Gastric cancer (GC)/CC genotypes was more protective than GG genotype after the C allele was regarded as mutant type
The combined effect of protective genotypes showed that participants with 3 protective genotypes had a 0.55-fold reduction in the development of CNS tumors
Summary
Central nervous system (CNS) tumors comprise 15–20% of all malignancies occurring in childhood and adolescence. Material and methods In this study, we assessed whether and to what extent AURKA gene single nucleotide polymorphisms (SNPs) (rs1047972 C > T, rs2273535 T > A, rs8173 G > C) were associated with CNS tumor susceptibility, based on a case–control analysis in 191 CNS tumor patients and 248 controls. We determined this correlation using odds ratios (ORs) and 95% confidence intervals (CIs). Central nervous system (CNS) tumors represent the most common solid malignancy in childhood [1, 2]. Most low-grade gliomas and almost all high-grade glioma are relapsed even developing into higher-grade gliomas [10]
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