Abstract
The Global Burden of Cancer (GLOBOCAN) revealed that there were 1,931,590 new cases and 935,173 deaths due to colorectal cancer in 2020. Treatment for colorectal cancer tends to be invasive and costly. Therefore, further research is needed on non-invasive complementary therapies that are safe and can be used to reduce the probability of recurrence in colorectal cancer patients at an affordable cost. The systematic literature review synthesized resources and presented them in a narrative review. Four databases, including PubMed, Research Gate, ProQuest, and Science Direct, were used to conduct the systematic reviews by following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) criteria. In this review, 36 articles were analyzed descriptively to help describe and summarize the data constructively. The results showed that complementary colorectal cancer therapy with Auricularia polytricha which contains active compounds, such as flavonoids, phenols, and beta-glucans, can increase the expression of miRNA-9, miRNA-217, miRNA-210, miRNA200c, and miRNA-132 which can improve the prognosis of colorectal cancer.
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