Aureomycin in the treatment of acute bronchiolitis of infants

Abstract

A series of sixty-four cases of acute bronchiolitis are presented, with thirty-two patients receiving aureomycin as the only antibiotic or chemotherapy, and the other thirty-two recciving penicillin, sulfadiazine, streptomycin, or combinations of them. Patients were admitted to the two groups alternately and have comparable age ranges, nose and throat cultures on admission, and cold agglutinin titer rises. The patients who received aureomycin were hospitalized on an average ofthree days less than those in the control group. Their nose and throat cultures became negative for pathogens one day sooner. Of the group of on aureomycin, 49 per cent were afebrile in twenty-four hourscompared to 43.7 per cent of the control group. Of the patients who had a relative leucopenia upon admission or a white blood count below 15,000, 63.2 per cent of the aureomycin treated group were afebrile in twenty-four hours, compared to 41.6 per cent of the control group. In the group with definite ;eucocytosis, 53.8 per cent of the aureomycin treated group, compared with 50 per cent of the control group, were afebrile in twenty-four hours. Of those treated with aureomycin who had a cold agglutinin titer rise, 54.5 per cent were afebrile in twenty-four hours, compared with 33.3 per cent of the control group. In both groups there was usually a lag of several days between the disappearance of fever and the return of respirations to normal. A series of sixty-four cases of acute bronchiolitis are presented, with thirty-two patients receiving aureomycin as the only antibiotic or chemotherapy, and the other thirty-two recciving penicillin, sulfadiazine, streptomycin, or combinations of them. Patients were admitted to the two groups alternately and have comparable age ranges, nose and throat cultures on admission, and cold agglutinin titer rises. The patients who received aureomycin were hospitalized on an average ofthree days less than those in the control group. Their nose and throat cultures became negative for pathogens one day sooner. Of the group of on aureomycin, 49 per cent were afebrile in twenty-four hourscompared to 43.7 per cent of the control group. Of the patients who had a relative leucopenia upon admission or a white blood count below 15,000, 63.2 per cent of the aureomycin treated group were afebrile in twenty-four hours, compared to 41.6 per cent of the control group. In the group with definite ;eucocytosis, 53.8 per cent of the aureomycin treated group, compared with 50 per cent of the control group, were afebrile in twenty-four hours. Of those treated with aureomycin who had a cold agglutinin titer rise, 54.5 per cent were afebrile in twenty-four hours, compared with 33.3 per cent of the control group. In both groups there was usually a lag of several days between the disappearance of fever and the return of respirations to normal.