Abstract
A new tetramic acid glycoside, aurantoside K, was isolated from a marine sponge belonging to the genus Melophlus. The structure of the compound was elucidated on the basis of spectroscopic analysis (1H NMR, 1H–1H COSY, HSQC, and HMBC, as well as high-resolution ESILCMS). Aurantoside K did not show any significant activity in antimalarial, antibacterial, or HCT-116 cytotoxicity assays, but exhibited a wide spectrum of antifungal activity against wild type Candida albicans, amphotericin-resistant C. albicans, Cryptococcus neoformans, Aspergillus niger, Penicillium sp., Rhizopus sporangia and Sordaria sp.
Highlights
Sponges (Porifera) are multicellular organisms that remain the most important source in the field of marine drug discovery
Marine sponges belonging to the genus Melophlus (Astrophorida, Ancorinidae) are promising sources of structurally unusual and diverse secondary metabolites
We report here the isolation, structure elucidation, and biological activity of a novel compound aurantoside K (1) resulting from these studies
Summary
Sponges (Porifera) are multicellular organisms that remain the most important source in the field of marine drug discovery. Sponges are a well-known source of new/novel bioactive natural products of pharmaceutical and medical relevance [1,2,3,4,5,6,7]. Marine sponges belonging to the genus Melophlus (Astrophorida, Ancorinidae) are promising sources of structurally unusual and diverse secondary metabolites. Meophlus spp. sponges have been reported to produce compounds primarily from three classes, tetramic acid derivatives [8,9,10], saponin derivatives [11,12], and depsipeptides [13] with potent and varied biological activities. Aurantosides have been reported to display antifungal and cytotoxic activities and have been isolated from sponges of the family. We report here the isolation, structure elucidation, and biological activity of a novel compound aurantoside K (1) resulting from these studies
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