Abstract
In this research, the fabrication of drug delivery systems based on oxidized multiwall carbon nanotubes (O-MWCNTs) was studied. Herein, TiO2 and Au were conjugated with O-MWCNTs to prepare efficient nanocarriers for dexamethasone (dex). The samples were characterized by Fourier transform infrared (FTIR), scanning electron microscopy (SEM), and X-ray diffraction (XRD). In addition, dex loading was studied using adsorption isotherms including Langmuir, Freundlich, Temkin, and Dubinin–Radushkevich. The results show that dex adsorption agreed well with the Freundlich isotherm. Increasing the TiO2 to O-MWCNT ratio from (1 : 4) to (1 : 2) can improve the adsorption capacity from 290 mg ⋅ g − 1 to 320 320 mg ⋅ g − 1 . The increasing Au amount increases the adsorption capacity from 437.78 mg ⋅ g − 1 (SA1) to maximum 476.19 mg ⋅ g − 1 (SA6). The maximum equilibrium binding energy A T 1.67 L ⋅ mg − 1 was obtained for SA2, and SA7 shows high binding strength between dex and the nanoadsorbent. Carbon nanotubes (CNTs) show good affinity with high loading capabilities for dexamethasone adsorption. The synthesized TiO2-O-MWCNTs:1/2 with the maximum removal percent (80%) was proposed as an appropriate nanocarrier for dexamethasone. Pseudo-first order, pseudo-second order, Elovich, and intraparticle diffusion models were investigated for all synthesized drug nanocarriers. According to regression coefficients, experimental data are in good agreement with the pseudo-second order model for all adsorbents except O-MWCNT/CTAB. Experimental results revealed that the Elovich model could account for the O-MWCNT/CTAB adsorbent.
Highlights
Dexamethasone is a type of steroid hormone and a strong combinatorial derived of the glucocorticoid hydrocortisone [1]. e chemical name of dex is 9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione with molecular formula C22H29FO5
Characterization of Prepared Nanocomposites. e synthesized samples were thoroughly characterized via Fourier transform infrared (FTIR), scanning electron microscopy (SEM) images, and X-ray diffraction (XRD) patterns
In order to identify the mechanism of dex adsorption, the FTIR spectra of various nanocarriers after dex loading were recorded, and the results were compared to the FTIR spectrum of O-multiwall carbon nanotubes (MWCNT) before dex loading
Summary
Dexamethasone is a type of steroid hormone and a strong combinatorial derived of the glucocorticoid hydrocortisone [1]. e chemical name of dex is 9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione with molecular formula C22H29FO5. Mesoporous silica has been combined with carbon nanotubes (CNTs) to improve the drug delivery capabilities [25]. Some earlier studies represent the use of MWCNTs for targeted delivery and controlled release of anticancer drugs such as doxorubicin (DOX) and paclitaxel [44, 45]. E main goal of this work is to prepare and study the novel nanocomposites based on multiwall carbon nanotubes as suitable carriers for dexamethasone. Both covalent functionalization of sidewalls and intrinsic defects were considered in this research. The adsorption isotherms and kinetic models were studied in this research. e results show that the prepared nanocomposites with high surface area can adsorb dex molecules effectively
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