Abstract
Augmenting Chemical Space with DNA-encoded Library Technology and Machine Learning.
Highlights
DNA-encoded library (DEL[1]) technology has emerged as one of the fastest and most cost-effective screening platforms available in industry both for hit discovery[2] as well as more recently for druggability and tractability assessments and successive prioritization of therapeutic targets in the early phase of drug discovery programs.[3]
The key principle of DELs is based on the combinatorial assembly of library members from chemical building blocks (BBs) and the corresponding tagging of each BB with unique DNA sequences in an alternating fashion of chemical reactions and DNA ligations
The DNA tags of library members allow for further exponential amplification by polymerase chain reaction (PCR), even minute amounts of binders can be detected and unambiguously identified by deep sequencing after elution from the target.[9]
Summary
DNA-encoded library (DEL[1]) technology has emerged as one of the fastest and most cost-effective screening platforms available in industry both for hit discovery[2] as well as more recently for druggability and tractability assessments and successive prioritization of therapeutic targets in the early phase of drug discovery programs.[3]. Augmenting Chemical Space with DNA-encoded Library Technology and Machine Learning
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