Abstract
Effects of diuresis on urinary amylase output were observed in control and pancreatectomized rats on the administration of tap water, glucose and amino acid solution. (1) Urine volume and urinary amylase output were increased as the concentration of glucose solution was increased. Amylase output in the urine revealed a positive correlation with the urine volume. (2) Augmentation of urinary amylase output was also observed in diuretic rats produced by the administration of amino acid solution. (3) Augmentation of urinary amylase output was not found in pancreatectomized rats, although the urine volume was more pronouncedly increased compared to control rats. (4) The urinary amylsae output revealed a positive correlation with the ratio of amylase clearance to creatinine clearance by the kidney in control rats, while the output remained unchanged over relatively wide range of the ratio in pancreatectomized rats. Above evidences indicated that urinary amylase output was significantly augmented by excessive diuresis and that the increased urinary amylase output originated from the pancreas
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