Abstract
Velocity of angiotensin formation has been studied using normal rat plasma and plasma from acute mercuric chloride intoxicated rats as renin substrate material. When the reaction velocity at the constant renin concentration is plotted for various concentrations of angiontensinogen, both substrate materials yielded identical velocities. Influence of plasma from mercuric chloride intoxicated rats upon the velocity of angiotensin formation from normal rat plasma was also examined. Plasma from acute mercuric chloride intoxicated rats did not affect the velocity of angiotensin formation from normal rat plasma and vice versa. These results suggest that acute mercuric chloride intoxication may neither reduce inhibitor(s) nor release activator(s) in plasma which influence the renin-angiotensinogen reaction. The mechanism responsible for augmented pressor response to the exogenous renin in acute mercuric chloride intoxicated rats was discussed.
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