Auditory responses to short-wavelength infrared neural stimulation of the rat cochlear nucleus.

Abstract

Pulsed Infrared laser is well-known for its high spatial resolution and contact-free stimulation mode. In order to improve the current auditory brainstem implants (ABI), 980 nm-short-wavelength infrared light was applied to stimulate the cochlear nucleus of rats. Single neural activity from contralateral inferior colliculus was recorded during laser stimulation. Animal experimental results showed that 980 nm laser could not directly activate neurons in cochlear nucleus and a photo-acoustic response was observed during stimulation, however, 980 nm laser produces an inhibitory effect on neural responses to sounds; After we added carbon nanoparticles onto the surface of animal cochlear nucleus, 980 nm laser could directly stimulate neurons and no interference between adjacent recording channels was observed. These findings indicated that with the enhancement of carbon nanoparticles, short-wavelength infrared neural stimulation (SW-INS) might be an effective method to overcome the defects of current ABIs. With this method, a new type of optical ABI with transcutaneous stimulating method is quite promising.