Abstract
Background: There is increasing interest in the impact of diabetes mellitus on cognitive functioning. Several studies found evidence of decreased cognitive performance in type 2 diabetics (T2DM). Since the P300
Highlights
There is increasing interest in the impact of diabetes mellitus on cognitive functioning
A statistically significant positive linear correlation between P300 latency and age was observed in the patients but not in the control group
A significant inverse correlation between P300 latency and amplitude was observed in diabetics both in Cz and Pz electrode positions (r= -0.43, p= 0.003 and r= -0.39, p= 0.01 respectively Figure 3), but not in controls (r= 0.06, p= 0.772 and r = 0.17, p= 0.432 respectively)
Summary
There is increasing interest in the impact of diabetes mellitus on cognitive functioning. Since the prevalence of type 2 diabetes mellitus (T2DM) increases with age and normal aging is associated with mild deterioration in cognition, the interplay between the aging process and the duration and magnitude of hyperglycaemia is expected to result in an accelerated cognitive decline. The P300 wave is the most studied ERP component and is considered cognitive because it is generated when subjects attend and discriminate stimuli that differ from one another on some dimension and are presented unequally in a random fashion. It is a broad, positive potential with maximal amplitudes at parietal and central midline recording sites and a peak latency of about 300–600ms.
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