Abstract
ABSTRACTObjective To establish reference intervals for cognitive potential P300 latency using tone burst stimuli.Methods This study involved 28 participants aged between 18 and 59 years. P300 recordings were performed using a two-channel device (Masbe, Contronic). Electrode placement was as follows: Fpz (ground electrode), Cz (active electrode), M1 and M2 (reference electrodes). Intensity corresponded to 80 dB HL and frequent and rare stimulus frequencies to 1,000Hz and 2,000Hz, respectively. Stimuli were delivered binaurally.Results Mean age of participants was 35 years. Average P300 latency was 305ms.Conclusion Maximum acceptable P300 latency values of 362.5ms (305 + 2SD 28.75) were determined for adults aged 18 to 59 years using the protocol described.
Highlights
Long latency auditory evoked potentials (LLAEPs) can be used in clinical practice as an objective measure of cognitive processes to assess auditory abilities, such as discrimination, memory, attention and detection of stimuli
Long latency AEPs enable the assessment of auditory information processing over time.[1]. These potentials are generated by several systems, primarily the thalamocortical and corticocortical auditory pathways, the primary auditory cortex and associative cortical areas,(2) and reflect thalamic and cortical activity in particular
Long latency AEPs are represented by a series of positive and negative waves.[4]. While some LLAEPs are sensitive to physical characteristics of the eliciting stimulus, others reflect cognitive processes, such as attention and stimulus categorization.[5]
Summary
Long latency auditory evoked potentials (LLAEPs) can be used in clinical practice as an objective measure of cognitive processes to assess auditory abilities, such as discrimination, memory, attention and detection of stimuli. Long latency AEPs enable the assessment of auditory information processing over time.[1] These potentials are generated by several systems, primarily the thalamocortical and corticocortical auditory pathways, the primary auditory cortex and associative cortical areas,(2) and reflect thalamic and cortical activity in particular. The P300 component, or cognitive potential, is a positive potential elicited by the recognition of a rare stimulus (oddball paradigm) within a series of frequent stimuli and corresponds to the largest positive wave after the N1-P2 complex.[6,7] P300 depends upon some abilities, such as attention, discrimination and memory, and reflects cortical activity.[8]. Novel studies are warranted to accurately determine normality parameters that may support the routine use of P300 for early recognition of several CNS changes in clinical settings
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