Abstract
1. 1. In depressive patients (DSM-III-R) treated with amitriptyline or amitriptylin oxide, the authors evaluated cognitive functions and auditory event-related potentials (AERPs) before (n = 29) and after therapy (n = 17). 2. 2. AERPs were elicited by an oddball paradigm. Cognitive functions were evaluated by the Zahlen-Verbindungs-Test, the Zahlen-Symbol-Test, and the Benton-Test. 3. 3. The amplitudes of the components N1, N2, and P3 showed a negative correlation with age and cognitive disturbances. The amplitude of N2 and the interpeak amplitudes N2/P3 and P3/slow wave were decreased with higher depression score. 4. 4. After treatment, the amplitude of N2 was increased and the sum of all peaks shifted to more negative values. 5. 5. The results suggest that the AERP amplitudes may reflect improvement from depression with special aspects of mood, cognition and drug profile.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Progress in Neuropsychopharmacology & Biological Psychiatry
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
