Abstract
Familial hypercholesterolemia (FH) is characterized by high total cholesterol (TC) and/or low-density lipoprotein cholesterol (LDL-C) concentrations in the blood and is associated with high rates of premature atherosclerotic disease. The identification and management of FH is based on clear guidance published by NICE in 2008 (CG71). The guidance states that FH should be considered in patients with TC>7.5 mmol/L (or LDL-C>4.9 mmol/L), if the levels remain high following a period of lifestyle modification and after excluding secondary causes.
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