Abstract

Due to the pandemic of COVID-19, a few new drugs and vaccines were officially approved by the EMA (European Medical Agency) and FDA (Food and Drug Administration) for prevention and treatment of SARS-CoV-2. The aim of this study is to analyze and highlight their potential audio-vestibular side effects as an ototoxic adverse reaction. The chapter was written by the review of the available literature in the scientific databases such as PubMed, ResearchGate, Scopus, and ScienceDirect, and in summaries of product characteristics as an official source of information. There were 39 publications and 15 summaries of product characteristics (as other sources of data), which were also used in this analysis. Adverse events could be permanent or disappear over time. Following treatment for COVID-19, the most frequent adverse audio-vestibular reactions reported in clinical trials and publications in the area of audiology and otorhinolaryngology were dizziness, blurry vision with dizziness, nasopharyngitis, dysgeusia, and tinnitus. As far as vaccines are concerned, dizziness as an ototoxic effect was uncommon and occurs only in hypersensitive people who experience anaphylactic shock. However, there is still a need to monitor ototoxic side effects because of potential interactions with other ototoxic drugs.

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