Abstract
In this study, we report a feasible aqueous chemical method to synthesize Au core–Ag shell nanoparticles (NPs) by seeding growth approach. The concentration of Au NPs plays an important role in growing the different thicknesses of Ag shells. The design of signaling aptamer utilizes the target-induced switching between an aptamer/DNA duplex and an aptamer/target complex. The surface enhanced Raman scattering (SERS) signal was enhanced upon the hybridization of the Raman reporter-labeled DNA released from the target-induced displacement with the captured DNA immobilized on the silicon substrate with Au–Ag core–shell NPs. This substrate with 12.4nm Ag shell shows high reproducibility, strong enhancement, and a low detection limit (1nM). The enhancement in DNA-based adenosine detection properties shall be advantageous in applications for other aptamer sensing systems.
Published Version
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