Abstract
Bacterial biofilms often hinder the healing of infected chronic wounds. Hence, it is significant to explore ways to destroy bacterial biofilms. In this work, a photothermal therapy strategy of designing Au clusters modified ZIF-8 MOFs (Au@ZIF-8) as peroxidase-like catalytic nanozyme was proposed for bacterial infected wound healing. Under near-infrared laser (NIR), the prepared Au@ZIF-8 present enhanced peroxidase-like activity and excellent photothermal response properties. Au@ZIF-8 achieved bacterial membrane disruption rate of 66.3% and MRSA clearance rate up to 97%. Au@ZIF-8 also catalyzed endogenous H2O2 to OH and achieved almost 97.4% healing rate in animal experiments. The prepared Au@ZIF-8 with peroxidase-like catalytic nanozyme properties has great potential in the treatment of infected diabetic wounds through bacterial membranes disruption and protein leakage promotion.
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