Abstract
The most severe sequel of measles virus infection is sub acutesclerosing pan encephalitis (SSPE), a fatal disease of the central nervous system that generally develops 7–10 years after infection. A 7 ½ year old boy presented with gradual difficulty in walking and speech along with jerky movements of right upper limb which progressed to become generalized and progressive loss of cognition was also observed within days of onset of symptoms. Diagnosis of SSPE was made on the basis of burst suppression pattern on EEG and anti measles antibody in CSF. A differential diagnosis of SSPE should be considered in all forms of acute encephalopathy for early diagnosis and treatment.J Nepal Paediatr Soc 2015;35(1):62-63
Highlights
Sub acutesclerosing pan encephali s (SSPE) is a progressive fatal disease of the central nervous system that is caused by a persistent measles virus infec on
A 7 1⁄2 year old male child presented with history of gradual difficulty in walking and speech along with jerky movements of right upper limb, which became generalized
A 7 1⁄2 year old male child was brought with complaints of gradually increasing difficulty in walking along with associated speech abnormality
Summary
Sub acutesclerosing pan encephali s (SSPE) is a progressive fatal disease of the central nervous system that is caused by a persistent measles virus infec on. A 7 1⁄2 year old male child presented with history of gradual difficulty in walking and speech along with jerky movements of right upper limb, which became generalized. A 7 1⁄2 year old male child was brought with complaints of gradually increasing difficulty in walking along with associated speech abnormality He had sudden jerky episodes of right upper limb which gradually progressed to generalized myoclonic spasms. He was drowsy irritable on presenta on and responding to mother’s voice but had increased tone in all four limbs and brisk reflexes, clonus was observed. A diagnosis of atypical sub-acute sclerosing pan encephali s was made as there is history of short onset latency. Child was treated with Sodium valproate, Clonazepam and Aman dine, but con nued to have episodes of myoclonus and there is no improvement in cogni on observed
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