Abstract
The classical Bartter syndrome is an uncommon tubular disorder of autosomal recessive inheritance, characterized by early childhood onset of polyuria, polydipsia, vomiting, dehydration, constipation and salt craving habit. The long-term outlook for patients with Bartter syndrome is not certain. If not properly treated, it may lead to failure to thrive and growth retardation. We herein report a case of 18-month-old girl child who presented chronic diarrhea and failure to thrive and then was diagnosed as a case of classical Bartter syndrome. She was successfully treated with potassium supplementation and ibuprofen therapy.
Highlights
Bartter Syndrome first described in 1960 but, over the years several phenotypic and genotypic variants of original description of Bartter syndrome have been identified [1,2]
The classical Bartter syndrome (BS) is characterized by early childhood onset with polyuria, polydipsia, vomiting, constipation, salt craving, severe dehydration, failure to thrive and growth retardation [3]. It is an uncommon tubular disorder, characterized by metabolic alkalosis, hyponatremia, hypokalemia, hypochloremia, with hyper-reninemia and hyperaldosteronemia, and normal or low blood pressure associated with increased loss of sodium, potassium, calcium and chloride in the urine [4]
Bartter syndrome was suspected in the view of metabolic alkalosis with high urinary excretion of chloride, hyponatremia, hypokalemia and hypochloremia and blood sample was sent for serum renin and aldosterone
Summary
Bartter Syndrome first described in 1960 but, over the years several phenotypic and genotypic variants of original description of Bartter syndrome have been identified [1,2]. It is an uncommon tubular disorder, characterized by metabolic alkalosis, hyponatremia, hypokalemia, hypochloremia, with hyper-reninemia and hyperaldosteronemia, and normal or low blood pressure associated with increased loss of sodium, potassium, calcium and chloride in the urine [4]
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