Abstract
Granulomatosis with polyangiitis (GPA) is part of the anti-neutrophil cytoplasmic antibodies (ANCA) associated vasculitis, mostly being ANCA-c (anti proteinase 3) positive. Primarily it involves the upper respiratory tract and kidneys having an increased mortality in the absence of early diagnosis and correct treatment. The most common renal involvement is pauci-immune crescentic glomerulonephritis. We present the case of a patient with GPA with a particular onset of interstitial nephritis, possible by vasa recta vasculitis, in the absence of glomerulonephritis.
Highlights
Granulomatosis with polyangiitis (GPA) is part of the anti-neutrophil cytoplasmic antibodies (ANCA) associated vasculitis, mostly being ANCA-c positive
A 71-year-old woman was admitted for oliguria and palpebral edema occurred in the last 36-48 hours
Since a definitive diagnosis of acute interstitial nephritis (AIN) can be established only by histopathology and some features in the clinical presentation of our case could point to systemic vasculitis, a kidney biopsy was performed in the fourth day of corticosteroid treatment
Summary
Cristina Capusa[1,2], Ana-Maria Mehedinti[2], Claudia Toma[1,3], Violeta Bojinca1,4 1Carol Davila University of Medicine and Pharmacy, Bucharest, Romania 2Dr. Carol Davila Teaching Hospital of Nephrology, Bucharest, Romania 3Marius Nasta Institute of Pneumology, Bucharest, Romania 4Sf. Maria Clinical Hospital, Bucharest, Romania
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