Atypical Myositis Presenting with Peripheral Neuropathy

Abstract

Necrotizing Autoimmune Myositis (NAM) is an Acute autoimmune disease of the proximal skeletal muscle. The increased rate of morbidity and mortality in NAM is related to the severety and extant of muscle weakness. Patients with NAM develop antibodies to a specific signal recognition particle (anti-SRP ab). Peripheral neuropathy is extremely rare during the course of the disease. We report the case of a 35 y old male, hospitalized for severe proximal and distal muscle weakness with positive anti-SRB ab and concomitant peripheral neuropathy. The outcome was severe respiratory failure and death.