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Abstract
A patient had infection with Mycobacterium intracellulare and anergy. Antituberculous chemotherapy proved ineffective. Repeated administration of dialyzable leukocyte extract (DLE) produced a sequential appearance of delayed type hypersensitivity in response to several antigens, as well as definitive clinical improvement. Unfortunately, the patient died from an Aspergillus fumigatus brain abscess. At autopsy, no evidence of active mycobacterial infection was found. DLE therapy may be indicated for the treatment of M. intracellulare infections which are unresponsive to chemotherapy. The disparity between the onset and course of skin test reactivities to different antigens suggests that DLE enhanced cellular immunity on an antigen-specific basis.
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