Atypical Functional Connectivity Associated with Autonomous Sensory Meridian Response: An Examination of Five Resting-State Networks.

Abstract

Autonomous sensory meridian response (ASMR) is a perceptual phenomenon in which specific auditory and/or visual stimuli consistently elicit tingling sensations on the neck, scalp, and shoulders, as well as a positive and relaxed emotional state. The “ASMR triggers” that initiate these responses generally consist of soft sounds (e.g., whispering), repetitive noises (e.g., tapping sounds), or videos of people performing socially intimate acts (e.g., watching someone brush her hair). Despite being a relatively common phenomenon, little is known about the neural substrates of ASMR. In the current research, resting-state functional magnetic resonance imaging (fMRI) was used to examine whether ASMR was associated with atypical patterns of functional connectivity. Seventeen individuals with ASMR and 17 matched control participants underwent an anatomical MRI scan and a resting-state fMRI scan. An independent components analysis was used to identify the default mode, salience, central executive, sensorimotor, and visual networks. An analysis of variance with group (ASMR vs. control) as a between-subjects variable was performed to contrast the functional connectivity of each of these networks. The results demonstrated that ASMR was associated with reduced functional connectivity in the salience and visual networks, and with atypical patterns of connectivity in the default mode, central executive, and sensorimotor networks.