Atypical Cutaneous Manifestations of Mucormycosis Infection in Immunocompromised Hosts—Review Article

Abstract

Abstract Mucormycosis is a rare invasive, rapidly spreading life-threatening fungal infection caused by mucorales species. Primary cutaneous mucormycosis occurs due to direct inoculation of the mold into the skin, whereas secondary cutaneous mucormycosis occurs due to hematogenous dissemination from the primary site of infection to the skin. Disruption of skin continuity is the portal entry for mucorales species in primary cutaneous mucormycosis. Immunosuppression conditions increase the risk of cutaneous mucormycosis infection. We present unusual cases of cutaneous mucormycosis that resulted from penetration of the perineum region by mucorales species in stool that was associated with fecal incontinence and progression to a black necrotic ulcer. These lesions look similar to ecthyma gangrenosum, atypical cutaneous herpes lesions, and decubitus ulcers. It is difficult to differentiate on a clinical basis alone. Early diagnosis and treatment are crucial steps to prevent complications of cutaneous mucormycosis infection.