Abstract
Author(s): Jardon, Meghan; Geng, Yipeng; Naini, Bita V; Sai, Victor | Abstract: [Original]Hepatocellular carcinoma (HCC) is the most common primary neoplasm of the liver, which arises from the parenchymal cells of the liver.1 Hepatocellular carcinoma usually develops in the setting of chronic background liver disease, such as cirrhosis or chronic hepatitis B or C infection. The diagnosis of HCC relies heavily on diagnostic imaging, and the high sensitivity and specificity of the Liver Imaging Reporting and Data System (LI-RADS) classification system allows for clinical decisions to be made based on imaging appearance alone.2 However, imaging classification systems such as LI-RADS rely on lesions following the multistep progression from dysplastic nodule to large, de-differentiated HCC in a step-wise fashion.3 In this case report, we will discuss an atypical case of a large, well-differentiated hepatocellular carcinoma with atypical imaging features, which presented in an asymptomatic young patient with no known liver disease.n[Updated]Hepatocellular carcinoma (HCC) is the most common primary neoplasm of the liver, and classically presents in the setting of background liver disease. In this case report, we present an atypical case of well-differentiated HCC which was detected in an asymptomatic 43-year-old man with no known underlying liver disease. We review the imaging features of this mass, which did not follow typical enhancement characteristics defined by the Liver Imaging Reporting and Data System (LI-RADS) classification criteria. The diagnosis was ultimately confirmed by surgical resection and pathologic analysis.
Highlights
Hepatocellular carcinoma (HCC) is the most common primary neoplasm of the liver, which arises from the liver parenchymal cells.[1]
The diagnosis of HCC in patients with these or other high-risk liver diseases relies heavily on diagnostic imaging because high sensitivity and specificity of the Liver Imaging Reporting and Data System (LI-RADS) criteria allows making clinical decisions based on imaging appearance alone.[2,5]
We report a case of a large, welldifferentiated hepatocellular carcinoma, which did not exhibit imaging features expected for its size
Summary
Hepatocellular carcinoma (HCC) is the most common primary neoplasm of the liver, which arises from the liver parenchymal cells.[1] Hepatocellular carcinoma usually develops on a background of chronic liver disease, such as cirrhosis or chronic hepatitis B or C. The diagnosis of HCC in patients with these or other high-risk liver diseases relies heavily on diagnostic imaging because high sensitivity and specificity of the Liver Imaging Reporting and Data System (LI-RADS) criteria allows making clinical decisions based on imaging appearance alone.[2,5] LI-RADS relies on characteristics that reflect multistep progression of lesions from a dysplastic nodule to a large, dedifferentiated HCC in a step-wise fashion.[3] We report a case of a large, welldifferentiated hepatocellular carcinoma, which did not exhibit imaging features expected for its size. The lesion occurred in a young patient with no known liver disease and displayed atypical enhancement characteristics
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