Abstract
Pulmonary Langerhans cell histiocytosis (PLCH) is a rare smoking-related interstitial lung disease affecting primarily young adult smokers. Diagnosis is made with typical radiographic findings of centrilobular nodules and cystic lesions on high resolution computed tomography (HRCT) confirmed with tissue biopsy. We describe a case of a 59-year-old man presenting with chronic tobacco use and cough who was found to have an atypical radiographic finding of miliary nodules on HRCT that was confirmed as PLCH on transbronchial lung biopsy.
Highlights
Pulmonary Langerhans cell histiocytosis (PLCH) is a rare interstitial lung disease of clonal dendritic cell infiltration that primarily affects young adult smokers with peak incidence at 20–40 years of age [1]
We describe an atypical presentation of bilateral miliary nodules requiring transbronchial lung biopsy to diagnose PLCH
Predominate and can transform from thick-walled (>2 mm) to thin-walled (
Summary
Pulmonary Langerhans cell histiocytosis (PLCH) is a rare interstitial lung disease of clonal dendritic cell infiltration that primarily affects young adult smokers with peak incidence at 20–40 years of age [1]. Predominate and can transform from thick-walled (>2 mm) to thin-walled (
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