ATX-S10(Na)-photodynamic therapy inhibits cytokine secretion and proliferation of lymphocytes

Abstract

Photodynamic therapy (PDT) is a new therapeutic modality for a variety of neoplasms, including skin tumors, lymphomas, as well as scleroderma. Now PDT using 5-aminolevulinic acid (ALA) is available for skin diseases and its effects on cytokine production have also been reported [ 1 Evans S. Matthews W. Perry R. Fraker D. Norton J. Pass H.I. Effect of photodynamic therapy on tumor necrosis factor production by murine macrophages. J Nat Cancer Inst. 1990; 82: 34-39 Crossref PubMed Scopus (168) Google Scholar , 2 Boehcke W.H. Konig K. Kaufmann R. Scheffold W. Prümmer O. Sterry W. Photodynamic therapy in psoriasis: suppression of cytokine production in vitro and recording of fluorescence modification during treatment in vivo. Arch Dermatol Res. 1994; 286: 300-303 Crossref PubMed Scopus (62) Google Scholar ]. ATX-S10(Na),13,17-bis(1-carboxypropionyl)carbamoylethyl-8-ethenyl-2-hydroxy-3-hydroxyiminoethylidene-2,7,12,18-tetramethylporphyrin sodium salt, is a new hydrophilic chlorine photosensitizer characterized by good accumulation in tumors [ 3 Nakajima S. Sakata I. Takemura T. Tumor localizing and photosensitization of photo-chlorin ATX-S10(Na). in: Spinelli P. dal Fante M. Marchesini R. Photodynamic therapy and biological lasers. Elsevier, Amsterdam1992: 531-534 Google Scholar , 4 Nakajima S. Sakata I. Hirano T. Takemura T. Therapeutic effect of interstitial photodynamic therapy using ATX-S10(Na) and a diode laser on radio-resistant SCC II tumors of C3H/He mice. Anticancer Drugs. 1998; 9: 539-543 Crossref PubMed Scopus (28) Google Scholar ], and rapid elimination in urine within 24–48 h. Thus ATX-S10(Na) is regarded as a good candidate for the second generation photosensitizer of PDT. Recent study from our laboratory has demonstrated that ATX-S10(Na)-PDT is effective for various skin tumors [ [5] Takahashi H. Itoh Y. Nakajima S. Sakata I. Iizuka H. ATX-S10(Na) photodynamic therapy for human skin tumors and benign hyperproliferative skin. Photodermatol Photoimmunol Photomed. 2004; 20: 257-265 Crossref PubMed Scopus (13) Google Scholar ].