Abstract
Binedaline is a new AD acting selectively or noradrenergic systems.Clinically it is reported to differ from classical AD by its rapidity of action. In order to give experimental support to this observation chronic electrophysiological studies were initiated. The chronic administration of various AD results in an attenuation of their inhibitory effect on the firing rate of LC neurons. This attenuation probably reflects modifications in the sensitivity of some adrenoceptors. As it is usually assumed that the delayed onset of the therapeutic effectiveness of AD is related to the development of these adaptive processes, the time-course evolution of the attenuation of the inhibitory effect of binedaline and desipramine on the firing rate of LC neurons was studied. The attenuation was apparent after 9 days of treatment with binedaline and after 14 days of treatment with desipramine. These data indicate that adaptive processes develop more rapidly with binedaline and give experimental support to clinical data.
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