Abstract
The effects of selective δ-opioid receptor antagonists on the discriminative stimulus properties of cocaine were examined in rats trained to discriminate between cocaine (10 mg/kg) and saline. Pretreatment with naltrindole (a non-selective δ-opioid receptor antagonist) and naltriben (a selective δ 2-opioid receptor antagonist), but not 7-benzylidenenaltrexone (a selective δ 1-opioid receptor antagonist), significantly attenuated the discriminative stimulus properties of cocaine. Naltrindole and naltriben attenuated the discriminative stimulus properties of doses of cocaine lower than the training dose. Although the effects produced by the training dose were not changed, our finding may have some bearing on the relative importance of the role of δ-opioid (especially δ 2-opioid) receptors in the discriminative stimulus properties of cocaine.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
